Three-time world champion boxer Israel Vazquez died at age 46 after suffering from cancer, WBC president Mauricio Sulaiman announced Tuesday, per ESPN.

"Israel Vazquez is finally resting in peace. May God give strength and support to his wife Laura, their children, family and friends during these difficult times...," Sulaiman posted on social media. "Thank you Israel for the so many great memories that you have given us through your actions inside the ring but most importantly outside of it. You are now eternal, rest in peace, everything will be all right."

The WBC announced in November that Vazquez was diagnosed with cancer, and a GoFundMe was set up to appeal for donations for his treatment.

Nicknamed "Magnifico," Vazquez was known for his speed and punching power. He held the IBF, WBC and The Ring super bantamweight titles over his 49-fight career, compiling a record of 44-5 with 32 knockouts on his way to becoming one of Mexico's most famed boxers.

Vazquez had a storied rivalry with fellow countryman Rafael Marquez, which they played out a series of four fights. They split the series 2-2, with Vazquez's loss to Marquez in May 2010 serving as the final professional fight of his career.

Legendary boxing trainer Freddie Roach reacted to Vazquez's passing in a statement to Boxing Scene: "Forever a world champion and legend in boxing. One of the best boxers I ever had the privilege of working with—a world champion. Israel, my friend, may you rest in peace now. My condolences to the Vazquez family and to all those who called Israel their friend."