The fifth-ranked Indiana Hoosiers finally get a chance to prove they belong among college football's elite programs in Week 13.

Indiana, who has not played a ranked foe in 2024, visits the Ohio State Buckeyes in a clash with significant College Football Playoff ramifications.

Indiana is undefeated, but there is fear that a big loss to Ohio State would drop it beneath some of the two-loss SEC teams at the bottom of the top 12.

Ohio State has not shown many flaws since its loss to the Oregon Ducks and it is a 12-point favorite at home.

The other playoff-altering games in Week 13 come from the Big 12, where the BYU Cougars and Colorado Buffaloes face tough road tests against the Arizona State Sun Devils and Kansas Jayhawks.

Week 13 Top 25 Schedule and Odds

Odds via DraftKings Sportsbook.

Friday, November 22

No. 23 UNLV (-7) at San Jose State (10 p.m. ET, FS1)

Saturday, November 23

No. 5 Indiana at No. 2 Ohio State (-12) (Noon ET, Fox)

Wake Forest at No. 11 Miami (-24) (Noon ET, ESPN)

No. 9 Ole Miss (-10) at Florida (Noon ET, ABC)

No. 13 SMU (-9) at Virginia (Noon ET, ESPN2)

No. 24 Illinois at Rutgers (-1.5) (Noon ET, Peacock)

UMass at No. 8 Georgia (-42.5) (12:45 p.m. ET, SEC Network)

UTEP at No. 10 Tennessee (-41) (1 p.m. ET, ESPN+)

Kentucky at No. 3 Texas (-20.5) (3:30 p.m. ET, ABC)

No. 4 Penn State (-11.5) at Minnesota (3:30 p.m. ET, CBS)

No. 14 BYU at No. 21 Arizona State (-3.5) (3:30 p.m. ET, ESPN)

No. 16 Colorado (-2.5) at Kansas (3:30 p.m. ET, Fox)

The Citadel at No. 17 Clemson (3:30 p.m. ET, CW)

Wofford at No. 19 South Carolina (4 p.m. ET, ESPN+)

No. 18 Army vs. No. 6 Notre Dame (-16) (7 p.m. ET, NBC)

No. 12 Boise State (-22.5) at Wyoming (7 p.m. ET, CBSSN)

No. 25 Washington State (-12.5) at Oregon State (7 p.m. ET, CW)

No. 7 Alabama (-14) at Oklahoma (7:30 p.m. ET, ABC)

No. 15 Texas A&M (-2.5) at Auburn (7:30 p.m. ET, ESPN)

No. 22 Iowa State (-6.5) at Utah (7:30 p.m. ET, Fox)

No. 5 Indiana (+12) at No. 2 Ohio State

The Indiana-Ohio State point spread suggests the odds makers do not believe the Hoosiers will contend with the Buckeyes.

The 12-point line is one of the bigger spreads you will see for a top-five contest in any college football season.

Indiana has at least proved that it can score in bunches. it eclipsed the 30-point mark in nine of 10 victories.

However, the last of those wins over the Michigan Wolverines might cause some concern among those backing the Hoosiers. Michigan hung with the Hoosiers in a 20-15 game.

While the Michigan result might be concerning, the Hoosiers have plenty of veteran players, starting with quarterback Kurtis Rourke, who can put that result in the rearview mirror and focus on the game at hand.

Ohio State's defense is no joke, but two of its three highest point concessions came against the Oregon Ducks and Penn State Nittany Lions.

The top-end talent has been able to score on the Buckeyes, who held six opponents to single-digit totals, and that is a promising sign for Indiana to at least remain competitive.

Beating Ohio State may be too much for Indiana, but there's certainly a path for it to keep the game close, cover the spread and prove to the CFB Playoff selection committee that it should remain in the top 12 with a defeat.

No. 14 BYU at No. 21 Arizona State (-3.5)

BYU's luck ran out in Week 12 at home against Kansas.

Now, the Cougars are in danger of losing a spot in the Big 12 Championship Game because they are running into one of the most underrated squads in the country.

Arizona State quietly won five of its last six games and it won two of its last three games on the road.

The Sun Devils have one of the most underrated players in the country in running back Cam Skattebo, who has over 1,500 yards from scrimmage and 13 total touchdowns.

Skattebo and Co. will move the ball on the BYU defense and the counter may be hard to come by for Jake Retzlaff and the Cougars.

BYU struggled to score at home in the last two weeks and now it goes up against an ASU defense that just limited the Kansas State Wildcats to 14 points.

Arizona State is playing to get into the Big 12 Championship Game. An ASU win would derail BYU's title game dreams, and in turn, potentially set up an ASU-Colorado clash on the first Saturday in December.

No. 16 Colorado (-2.5) at Kansas

Colorado does not have an easy task on its hands in Week 13.

The Buffaloes face the other streaking team in the Big 12, the Kansas Jayhawks, who are fresh off a road upset over BYU.

Kansas played far better in the last month with a 3-1 mark and upsets over BYU and the Iowa State Cyclones, so there's good reason for it to be just a 2.5-point underdog.

Colorado is in the middle of a surge of its own, and while the offense gets its share of the headlines, the Buffaloes defense is playing much better.

The Buffaloes have not allowed an opponent under 30 points in four games. Their offense produced at least 34 points in every game during that stretch.

If that trend continues, Colorado should cruise and move one step closer to the Big 12 Championship Game.

Kansas can certainly put up a fight, but it might be out of gas after battling through three straight games against ranked foes, a run that began with a close loss to Kansas State.

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