It's one of the Premier League's most heated rivalries: the north London derby.

It's also the featured fixture of Week 4's slate of games as Tottenham Hotspur play host to Arsenal in a measuring-stick match that will have implications at the top of the table.

Elsewhere, Manchester City and Liverpool will look to continue their perfect starts to the season. The Citizens take on Brentford at the Etihad Stadium, while the Reds welcome Nottingham Forest to Anfield.

And things kick off on Saturday at St. Mary's Stadium as a reeling Manchester United squad take on Southampton. A loss to the Saints could put United manager Erik ten Hag in the firing line of the club's new owners.

As always, B/R's Leo Collis and Nick Akerman break down every Premier League match from this week's slate and provide their expert predictions.

Disagree with their picks? Submit your own thoughts now in the comments section of the app.

Southampton vs. Manchester United

DraftKings odds: Southampton +330, Draw +295, Manchester United -130

Southampton are pointless and have scored just one goal in three matches, including a game in which they faced 10 men for over an hour. Murmurings are becoming louder; there's no way the promoted team can stay in the Premier League this season, right?

Manchester United are the perfect opponents to flip that narrative.

Recently battered by Liverpool and stunned late by Brighton, Erik ten Hag's side have retained the frailty that led to an abysmal eighth-place finish last season. The midfield is as open as ever—with Manuel Ugarte likely to make his debut against the Saints—as United again look well off the pace in the hunt for UEFA Champions League places.

A fired up St Mary's could make this a hellish game for Ten Hag. You don't want to be the side that hands Southampton their first points back in the big league, especially if you're already under pressure.

There's decent fight to the home side, who can set the tone with some big early tackles and by showing United no respect. Time to go Sunday League; get in their faces, fight for the badge, give 110 per cent. All the things that make United clam up.

This should be tighter than many United supporters will hope. Anything other than victory will thrust Ten Hag to the top of the "next manager to be sacked" odds.

-Nick Akerman

Nick: Southampton 1-2 Manchester United

Leo: Southampton 0-2 Manchester United

Brighton Hove & Albion vs. Ipswich Town

DraftKings odds: Brighton & Hove Albion -285, Draw +425, Ipswich Town +700

Brighton & Hove Albion's momentum was slowed against Arsenal last time out.

Although a draw with last season's runners-up would typically be a decent result, the Seagulls will feel they missed an opportunity for a big three points while playing against 10 men for nearly half of the game.

Still, it's seven points from a possible nine so far, and a match against Ipswich Town should allow them to get back in the win column.

The Tractor Boys won't be so easy to tip over, though. They picked up their first Premier League point for 22 years against Fulham two weeks ago, and they showed battling qualities against Liverpool and Manchester City that will put them in good stead at the Amex Stadium.

The odds favor Brighton, and so do I, but Ipswich will at least get on the scoresheet.

-Leo Collis

Nick: Brighton 3-0 Ipswich

Leo: Brighton 2-1 Ipswich

Crystal Palace vs. Leicester City

DraftKings odds: Crystal Palace -170, Draw +310, Leicester City +425

It's no coincidence Crystal Palace began to look sharper during their 1-1 draw with Chelsea before the international break.

The conclusion of the summer transfer window brought closure on the immediate future of their two biggest stars, with Marc Guehi and Eberechi Eze staying at Selhurst Park despite continued speculation they would leave.

Both are vital to Oliver Glasner's plans, highlighted by Eze's stunning goal against the Blues and Guehi's stock continuing to rise as a dominant centre-back.

Supporters will be hyped to see a more settled team in a home game against a Leicester side that is proving tough to beat upon its return to the top flight, despite only accumulating one point from Spurs, Fulham and Aston Villa.

Palace will prove too much for the Foxes, though.

Jean-Philippe Mateta should look more at home now he's had time to get back up to speed following the Olympics. He's vital to Glasner's success and hasn't looked Premier League-ready so far this campaign; failing to hold the ball up, make runs or finish chances you'd expect him to gobble up.

It's time to back him to get rolling against a Leicester side that will again make it difficult but come up slightly short.

-Nick Akerman

Nick: Crystal Palace 2-1 Leicester City

Leo: Crystal Palace 2-0 Leicester City

Fulham vs. West Ham United

DraftKings odds: Fulham +145, Draw +250, West Ham United +175

You can't fault or question Fulham's ambition, but it's not quite clicking yet this season for them.

A 1-1 draw against Ipswich before the international break was disappointing, even away from home, and things won't be much better against West Ham United.

A couple of smart signings in Joachim Andersen and Sander Berge might get their first starts, and Reiss Nelson could make an appearance, but it will still be a few weeks until this Fulham squad achieves harmony and hints at its potential.

The Hammers won't be happy with three points from nine so far, but when one of those opponents is Manchester City, it doesn't seem quite so bad.

This is the game for West Ham to show what they can really do. Mohammed Kudus has demonstrated the pace, directness and trickery that earned him plenty of fans last season, but he's not yet contributed to a goal in this Premier League season. That will change on Saturday.

In the slightly more low-key London derby of the weekend, bank on West Ham to come out on top.

-Leo Collis

Nick: Fulham 2-2 West Ham United

Leo: Fulham 1 - 2 West Ham United

Liverpool vs. Nottingham Forest

DraftKings odds: Liverpool -475, Draw +600, Forest +1000

Liverpool entered the brief Premier League hiatus in the best possible fashion, outplaying Manchester United at Old Trafford and securing a 3-0 win, which perhaps should have been more.

Confidence is high at Anfield, with Arne Slot quickly settling in and easing the feeling of loss among fans following Jürgen Klopp's exit. Ryan Gravenberch has been a revelation, Luis Diaz is in remarkable form, and Mohamed Salah is performing at a level that's exceeding the last couple of seasons.

Nottingham Forest won't do much to stutter that momentum. They are undefeated so far, picking up five points in their opening three matches. It's a positive start to the campaign, perhaps suggesting a relegation battle won't be on the cards this season.

But it's difficult to see them getting anything out of a Liverpool side that is performing at breakneck speed and demonstrating a clinical edge. Forest will just want to keep the scoreline low.

-Leo Collis

Nick: Liverpool 3-0 Nottingham Forest

Leo: Liverpool 4-0 Nottingham Forest

Manchester City vs. Brentford

DraftKings odds: Manchester City -550, Draw +700, Brentford +1100

Ominous. Inevitable. Manchester City already look like they could stroll to another Premier League title.

Erling Haaland's back-to-back hat-tricks grab the headlines, but Pep Guardiola's side have eased to wins over Chelsea, Ipswich and West Ham without their most important player in Rodri. Sávio already looks a terrific signing, despite missing the last match through injury. Everything about the City machine is purring with zero fuss.

How do you compete with that?

Brentford have started the season well, playing attacking football en route to two wins from three, and now have the Ivan Toney saga behind them.

The amended frontline of Bryan Mbeumo, Yoane Wissa and Kevin Schade is interlinking well, combining devastating pace with pass-and-move tactics that keep getting them into dangerous positions. The Bees are well-placed to trouble most sides this year, but they won't trouble City at the Etihad.

Call it what you want, but the champions' complete domination and that slow, squeezing of life they inflict on opponents will halt Brentford's zest like it halts everyone else.

-Nick Akerman

Nick's prediction: Manchester City 3-0 Brentford

Leo's prediction: Manchester City 4-1 Brentford

Aston Villa vs. Everton

DraftKings odds: Aston Villa -230, Draw +370, Everton +550

It's been a long two weeks for Everton. Hell, it's been a long few years.

Uncertainty around the club's ownership and future were well-represented on the pitch last time out as the Toffees threw away a 2-0 lead by conceding three in the final nine minutes against Bournemouth.

It was ridiculous and a snapshot of a team that looks like it's in another relegation fight.

Villa Park is not the place you want to visit when the pressure is on. Two away wins and a home defeat to Arsenal have Unai Emery's side moving nicely, even with Ollie Watkins being completely off the pace. His missed chances shouldn't be too much of a worry for now.

Amadou Onana's brilliant introduction to the side will worry his former employers. He's already improved since leaving Everton, even in three games, scoring two goals and playing with the all-encompassing dominance the Goodison Park fans never got to see consistently.

Things seem to just keep getting worse for Sean Dyche, so it wouldn't be a major surprise to see Onana score again and Villa romp through their opponents with no issues at all.

-Nick Akerman

Nick: Aston Villa 3-0 Everton

Leo: Aston Villa 2-0 Everton

AFC Bournemouth vs. Chelsea

DraftKings odds: AFC Bournemouth +225, Draw +295, Chelsea +100

Chelsea might be the most difficult side to predict in the Premier League. While Enzo Maresca is doing a good job of trying to settle things down in the squad after a period of wild turnover, the Blues' results are going from one extreme to another.

In five games across all contests, they've been comfortably beaten by Manchester City, eased past Servette in Europa Conference League qualifying, thrashed Wolverhampton Wanderers, lost in the return fixture against Servette and played out a lackluster draw with Crystal Palace.

A visit to Bournemouth is next on the horizon, but Chelsea shouldn't expect a fun trip to the seaside. The Cherries are coming off a remarkable comeback victory against Everton that will have morale at a notable high at the Vitality Stadium.

Against a vulnerable Chelsea team, they might just fancy another dramatic win.

Quality speaks for something, though. And in the spirit of fluctuating results, Chelsea will narrowly grab three points—and then probably follow that up with a loss at West Ham.

-Leo Collis

Nick: Bournemouth 2-3 Chelsea

Leo: Bournemouth 1-2 Chelsea

Tottenham Hotspur vs. Arsenal

DraftKings odds: Tottenham Hotspur +210, Draw +260, Arsenal +120

The weekend's marquee contest is the first north London derby of the season. Strap yourselves in, folks.

Tottenham Hotspur are the hosts for this one, and Arsenal will not be too happy to follow up a dispiriting draw against Brighton with a trip to the home of their most hated rivals.

The Gunners will need to pick themselves back up, but a few key players will not be offering a helping hand. Declan Rice is suspended following a silly red card against the Seagulls, Martin Ødegaard picked up an ankle injury on international duty with Norway, and new signing Mikel Merino is not available after a training-ground shoulder injury.

That leaves a potential engine room featuring Thomas Partey and Jorginho, while Leandro Trossard or Kai Havertz might be asked to plug a hole in the middle of the park.

Arsenal will be vulnerable, and it will be up to Spurs to exploit that. A bit of energy in the center circle could leave the makeshift Gunners midfield chasing shadows. Dejan Kulusevski and James Maddison might really enjoy themselves.

Spurs should have a more-or-less full squad available, with Micky van de Ven expected to recover from a knee problem and Dominic Solanke likely to return from an ankle injury.

With manager Ange Postecoglou already under pressure following last season's woeful final stretch and a slow start this season, he'll need all the help he can get.

Alas, it won't be more than a point for the Australian. Arsenal will make things hard for Spurs, likely relying on a deep midfield rather than a progressive one, and their defense is still formidable. Goals won't be in abundance, but each side nicking one seems likely.

-Leo Collis

Nick: Tottenham Hotspur 1-2 Arsenal

Leo: Tottenham Hotspur 1-1 Arsenal

Wolverhampton Wanders vs. Newcastle United

DraftKings odds: Wolverhampton Wanderers +225, Draw +270, Newcastle United +110

Newcastle's win over Tottenham was an important moment for Eddie Howe's team.

Although unbeaten, the Magpies hadn't hit their stride until Ange Postecoglu's side came to town. It's a result they need to build on against a Wolves side that is taking steps to recover following the 6-2 loss to Chelsea in August.

Wolves' draw with Nottingham Forest last time out began to look better, but an extremely positive pre-season is long gone. Gary O'Neil's team attack wildly with numbers. It's entertaining to watch but detrimental to results.

Some kind of balance needs to be found if they're to impose themselves like they should. Wolves really could be a top-half team.

Newcastle will exploit their gung-ho style if it continues. Alexander Isak, Harvey Barnes and Anthony Gordon are built for counter-attacking play and could enjoy a fruitful game if previous lessons haven't been acted on.

It's difficult to look the other way right now; one team is playing under its capability and getting results, while the other is playing under its capability and coming up short.

It will be interesting to see what improvements are noticeable after the international break.

-Nick Akerman

Nick: Wolverhampton Wanderers 1-2 Newcastle United

Leo: Wolverhampton Wanderers 1-1 Newcastle United