It's the signature fixture of English football: Manchester United vs. Liverpool.

The great rivals are England's two most successful clubs and meet on Sunday in this week's featured game of Week 3.

Liverpool are enjoying life under new head coach Arne Slot and have yet to surrender a goal this season. But a match at Old Trafford is a different story for Liverpool and the Reds failed to record a win against Manchester United last season.

In the early kickoff on Saturday, a matchup of 100 percent records features Arsenal playing host to Brighton & Hove Albion at the Emirates Stadium.

So, who's coming away with three points this week? Who's going down to defeat? Here, Leo Collis and Nick Akerman break down every game this week.

Disagree with their predictions? Sound off now in the comments section of the app.

Last Week's Results

Saturday, Aug. 24

Brighton & Hove Albion 2 Manchester United 1

Crystal Palace 0 West Ham United 2

Fulham 2 Leicester City 1

Manchester City 4 Ipswich Town 1

Southampton 0 Nottingham Forest 1

Tottenham Hotspur 4 Everton 0

Aston Villa 0 Arsenal 2

Sunday, Aug. 25

AFC Bournemouth 1 Newcastle United 1

Wolverhampton Wanderers 2 Chelsea 6

Liverpool 2 Brentford 0

Prediction results

Nick Akerman 3-2

Leo Collis 4-1

Season totals

Akerman 5-5

Collis 8-2

Arsenal vs. Brighton & Hove Albion

DraftKings odds: Arsenal: -300, Draw: +500, Brighton & Hove Albion: +700

Two unbeaten sides meet at the Emirates Stadium in this week's early kick-off.

Arsenal lived dangerously during their 2-0 win against Aston Villa and were an Ollie Watkins open-goal miss away from conceding their first of the season. David Raya's excellent save shortly after provided a stark reminder that it's incredibly hard to breach the Gunners' backline even when they aren't at their sharpest.

Patience within this Arsenal team continues to win matches. Mikel Arteta knows his team will take chances. He also trusts his forwards to be clinical and has match-winners across the frontline. It didn't matter that Kai Havertz and Gabriel Martinelli were quiet at Villa Park, because Leandro Trossard proved again he is a game-changing sub from the bench.

Brighton are also showing signs of a fruitful season ahead.

New manager Fabian Hürzeler has settled straight in with an attractive brand of football that looks to unleash the pace of Kaoru Mitoma and Yankuba Minteh down the wings while filling the box with numbers.

Brighton's directness won a tight game against Manchester United; a result that wasn't exactly a surprise. But Hürzeler's use of João Pedro, who scored the winner, was particularly interesting.

The Brazilian dropped off the frontline to help distribute the ball and worked hard across United's box, never allowing the defence to settle. He needs to do the same against William Saliba and Gabriel if Brighton are to have any chance against the Gunners.

This should be a decent game, but Arsenal are incredibly consistent and building towards another title challenge. That will continue in north London on Saturday.

Prediction: Arsenal 2-0 Brighton & Hove Albion

-Nick Akerman

Brentford vs. Southampton

DraftKings odds: Brentford: -135, Draw: +300, Southampton: +350

Brentford are refreshed and ready to cause havoc this season.

Both their win over Crystal Palace and defeat to Liverpool included some cutting attacking play between Bryan Mbeumo and Yoane Wissa, who are forming an interesting bond now Ivan Toney is heading for the exit.

Head coach Thomas Frank looks to have his side back to where they should be—competing in every game and troubling bigger sides—so we can expect a fruitful afternoon when Southampton come to town.

It's too early for alarm bells, but a faint ringing might be heard in the distance for Saints fans.

They're yet to score on their Premier League return. When you consider that included most of a game against a 10-man Newcastle United and a home game versus Nottingham Forest, it's already beginning to look like this year might be a long, hard slog.

They have the type of threat that rips up the Championship— Adam Armstrong scored 52 goals and provided 18 assists in his last two seasons there— but how that translates to top-flight output remains to be seen.

Even if they nab a goal, it's unlikely Southampton will get their first points of the season this weekend.

Prediction: Brentford 3-1 Southampton

-Nick Akerman

Everton vs. AFC Bournemouth

DraftKings odds: Everton: +175, Draw: +245, AFC Bournemouth: +155

Everton's season-long farewell to Goodison Park has started extremely badly. Whooped 3-0 on opening day by Brighton and then slapped about during their 4-0 defeat at Tottenham last weekend. Manager Sean Dyche just isn't getting what we'd expect from his players.

Granted, his tactics are limited at best, but his sides are usually well-drilled, organised and built around winning physical battles. We're not seeing any of that right now. Even worse, individual mistakes are creeping in, as we saw with Jordan Pickford's moment of poor concentration against Spurs.

Bournemouth are exactly the type of side that can elevate Everton's mild panic into a full-blown crisis.

Consecutive 1-1 draws against Forest and Newcastle is a good start to the Cherries' season. New signing Evanilson had a positive debut against the Magpies, injecting energy and fight to push the side forwards. They're exactly the type of opponents Everton would expect to beat and then come up short against.

Goodison should play host to a very tight match. One has to ask how often we'll be able to say that this season if Everton keep trending the way they are.

Prediction: Everton 1-1 AFC Bournemouth

-Nick Akerman

Ipswich Town vs. Fulham

DraftKings Odds: Ipswich Town: +195, Draw: +240, Fulham +135

To say Ipswich Town have been thrown in at the Premier League deep end is a gross understatement. It feels more like they've been plunged into the Mariana Trench.

Opening fixtures against Liverpool and Manchester City in your first two top-flight games for more than two decades is a baptism of molten lava, and to be fair to the Tractor Boys, they did not disgrace themselves.

After holding Liverpool to just two goals and opening the scoring at the Etihad Stadium, positives can be taken, and the visit of Fulham on Saturday will be a much nicer way to spend the afternoon.

The Cottagers got their first win of the campaign over Leicester City, with Emile Smith Rowe bagging his first goal for the club and Alex Iwobi finishing his chance with aplomb to make the controversial Wout Faes equalizer all but irrelevant.

Fulham would be wise not to take this one lightly, as Ipswich showed plenty in their opening fixtures to prove they can beat the drop this season. The signing of Sammie Szmodics has instantly paid dividends after he squeezed one under Ederson's legs on Saturday.

With the Portman Road crowd behind them, the Tractor Boys will grab a narrow but deserved first win of the season.

Prediction: Ipswich Town 1 - 0 Fulham

-Leo Collis

Leicester City vs. Aston Villa

DraftKings odds: Leicester City: +340, Draw: +290, Aston Villa: -130

Villa's start to the campaign might have looked a lot different if Watkins was fully fit. His uncharacteristic misses against Arsenal are not something we can expect to see often when England's Euro 2024 hero is back to full sharpness. Leicester fans will be hoping there's at least one more week until that happens.

Both of these teams will be content with their starts. Leicester's 1-1 draw with Spurs and 2-1 defeat to Fulham highlights one important factor: They have the quality to fight.

It's pivotal to show that early when promoted to the Premier League, as it holds off questioning and the inevitable "straight back down" talk far longer than, say, Southampton are managing.

Villa will be another tough match for the Foxes. Despite Watkins' poor form, Unai Emery's side have played some dangerous football. Morgan Rogers was excellent against Arsenal. His ability to skip beyond multiple players is an incredible asset that allows the rest of the team time to sprint into free space. His quick start has helped fill that Watkins gap and may keep Leicester's midfield unwilling to move too far up the pitch.

Even so, we should expect the Foxes to have a good go at this one. It's all they can do in the quest to survive. But Villa have too much quality and are too good in possession to come unstuck here.

Prediction: Leicester City 1-2 Aston Villa

-Nick Akerman

Nottingham Forest vs. Wolverhampton Wanderers

DraftKings Odds: Nottingham Forest: +105, Draw +260, Wolverhampton Wanderers: +245

The meeting between Chelsea and Wolverhampton Wanderers last weekend was a thrillingly close contest for the first 45 minutes.

Both sides traded goals to go in 2-2 at the break, but then the Blues' Cole Palmer and Noni Madueke truly showed up, and Wolves were handed a 6-2 defeat.

It shouldn't be such a dispiriting outing against Nottingham Forest, but there is already a four-point gap between the two sides at this early stage of the season.

Forest have looked energetic but wasteful so far, with 16 shots on target producing only two goals.

That's great news for Wolves, as another drubbing will not be welcomed again so quickly. But they still won't pick up any points.

Forest might not quite solve their inefficient output in front of goal, but they will again grab a narrow victory.

Prediction: Nottingham Forest 1-0 Wolverhampton Wanderers

-Leo Collis

West Ham United vs. Manchester City

DraftKings Odds: West Ham United: +600, Draw: +425, Manchester City: -265

Manchester City have wasted no time reminding the league how ruthless they can be.

While Ipswich grabbed a surprising lead in their last match, it didn't last long, as the Citizens scored three in the space of four minutes to put any hopes of a remarkable upset to rest.

Erling Haaland has four goals in two games, and he already looks unbeatable in the Golden Boot race. Against West Ham United, a team that has major weaknesses in the back line, he should add to that total in no time at all.

The Hammers grabbed two goals in a five-minute span to claim victory over Crystal Palace, but the performance as a whole wasn't too much to shout about.

Mohammed Kudus remains electric, but even his flashes of brilliance can't add too much life to a lacklustre side. Julen Lopetegui needs to make some changes, and fast.

City should have the run of the London Stadium on Saturday evening, and it won't be a close contest.

Prediction: West Ham United 0-3 Manchester City

-Leo Collis

Chelsea vs. Crystal Palace

DraftKings Odds: Chelsea: -175, Draw: +340, Crystal Palace: +425

If Chelsea have any traits from last season lingering following Enzo Maresca's move into the dugout, Crystal Palace will win this 3-0.

Time and again in the 2023-24 campaign, the Blues would pull off a remarkable victory or show signs of improvement only to regress significantly the following week.

A 6-2 win at Wolves was an entertaining way to herald the start of a new era, but let's not get excited just yet.

Cole Palmer is the beating heart of this team, and his brilliance on Sunday and a burgeoning relationship with Noni Madueke saved Chelsea from what could have been a frustrating afternoon. But they need more than that to truly make their status as a "Big Six" club known once more.

Crystal Palace, meanwhile, haven't demonstrated the blistering form that propelled them into the Premier League's top half at the end of last season.

Whether it's a mild Olympic hangover for Jean Philippe-Mateta, the loss of Michael Olise or other clubs figuring out manager Oliver Glasner's methods, it's not quite clicking yet for the Eagles.

Despite Chelsea's reputation for slipping up after a good week, Palace won't get back on the right track here. It will be a close one, but the Stamford Bridge side will claim the victory.

Prediction: Chelsea 2-1 Crystal Palace

-Leo Collis

Newcastle United vs. Tottenham Hotspur

DraftKings Odds: Newcastle United: +145, Draw: +295, Tottenham Hotspur: +150

One win and one draw each for Newcastle United and Tottenham Hotspur is an acceptable but disappointing start to the campaign for two sides with much greater ambitions.

Spurs have more momentum going into this one, though, having put four past an admittedly disastrous Everton side last time out. Newcastle, meanwhile, could have easily lost to Bournemouth had Dango Ouattara's late winner counted—and perhaps it should have.

Sandro Tonali could make his return for the Magpies after a 10-month suspension for breaching the Football Association's betting rules, but even if he starts, it won't make a significant difference to a side that has so far stumbled out of the blocks.

With Dominic Solanke expected to be out until after the international break, Heung-min Son should continue in a centre-forward role that treated him so well against the Toffees, resulting in two goals for the South Korean.

Tottenham might just have the edge in terms of quality and recent form, but that might be wiped out by the atmosphere inside St. James' Park. With that in mind, I'm plumping for a draw that neither side wants.

Prediction: Newcastle United 2-2 Tottenham Hotspur

-Leo Collis

Manchester United vs. Liverpool

DraftKings odds: Manchester United: +265, Draw: +310, Liverpool: -115

Everything we know about Erik ten Hag's Manchester United pointed towards them losing the game to Brighton in added time.

Even after a fairly decent display and an unlucky disallowed goal, even after fighting back, the world's worst psychic would have surmised they'd leave the Amex Stadium with zero points. It's just what they do.

A home match against north-west rivals Liverpool is probably not the next game United fans want. Arne Slot is already impressing at Anfield.

The Reds aren't quite as gung-ho, but we're seeing tremendously put-together passing moves that are ripping opponents apart. Some of the play in Sunday's 2-0 win over Brentford was impossible to defend, including the brilliant counter-attacking goal for the opener.

Liverpool's midfield still isn't quite right and there are vulnerabilities from set-pieces. United will need to exploit these areas if they're going to get anything from this game.

Ten Hag is staring down the barrel at two potential defeats in three matches, not the type of form that Jim Ratcliffe and the INEOS crew surprisingly kept him on for.

Right now, Liverpool have too much for a United side that still looks blunt in front of goal. Expect major questions to be asked of Ten Hag after this one.

Prediction: Manchester United 0-3 Liverpool

-Nick Akerman