The highly-anticipated Week 13 matchup between the Philadelphia Eagles and San Francisco 49ers was bound to get a little chippy, but tensions certainly escalated in the third quarter.

Following a reception from Philadelphia Eagles wide receiver Devonta Smith, San Francisco 49ers linebacker Dre Greenlaw was involved in a sideline altercation with Eagles chief security officer Dom DiSandro.

The altercation led to both Greenlaw and DiSandro being ejected from the game. DiSandro is in his 25th season with the Eagles organization and also serves as a senior advisor to the general manager, per the team's website.

San Francisco coach Kyle Shanahan spoke on the situation after the game:

NFL senior vice president of officiating Walt Anderson discussed the altercation after the game:

The NFL is reportedly "likely to take action" against DiSandro for his actions, per Mike Florio of ProFootballTalk.

The incident occurred as the Eagles trailed 21-6, putting them in danger of losing their second game of the season.

Beyond this however, it is the first meeting between the two teams since last season's NFC Championship, a game the Eagles won 31-7 after the 49ers experienced bad injury luck at the quarterback position.

This matchup could very well be a preview of another future playoff game as both teams look formidable in the NFC. While the Eagles currently have a better record, the head-to-head result could eventually play a role in determining playoff seeding and possibly home-field advantage in said playoff matchup.